Rumored Buzz on ketamine risks and benefits
Metabolism Ketamine is metabolized by using N-dealkylation for the active metabolite norketamine mostly by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation of the cyclohexone ring to type hydroxynorketamine compounds via CYP-dependent pathways, which are conjugated with glucuronic acid and subseque